Renal Ischemia-Reperfusion Injury Amplifies the Humoral Immune Response
نویسندگان
چکیده
منابع مشابه
Amelioration of rat renal ischemia/reperfusion injury by L-Nil
Introduction: Ischemia/reperfusion (IR) injury involves a complex interrelated sequence of events. High levels of nitric oxide (NO) are generated with inducible form of nitric oxide synthase (iNOS) leading to the renal IR injury and glutathione (GSH) depletion. The present study was designed to investigate the effect of L-Nil (N6- (1-Iminoethyl)-L- lysine.hydrochloride), a selective inhibito...
متن کاملRapamycin Ameliorates Renal Ischemia/Reperfusion Injury via Remodeling Immune Microenvironment
Immunosuppressive therapy is necessary for patients receiving organ transplantation to prevent allo-rejection mediated by immune cells. Meanwhile, certain immunosuppressive drugs also have an important impact on allograft IR injury. Rapamycin, the inhibitor of the Mammalian Target of Rapamycin (mTOR) complex, is a kind of potent immune suppressor widely used in clinic. In recent years, great sc...
متن کاملAngiogenic response following renal ischemia reperfusion injury: new players.
Ischemia-reperfusion (IR) injury can negatively influence the short- and long-term outcomes of kidney transplantation because it promotes acute tubular necrosis and tissue scarring and activates innate alloimmunity. The adaptive responses to IR are centrally involved in reducing tissue damage but can also be deleterious when they activate programmed cell death and inflammation. The HIF-1α-media...
متن کاملBerberine Ameliorates Renal Functional Disorders and Pulmonary Tissue Injury Following Renal Ischemia/Reperfusion in Rats
Introduction: This study investigated the effect of berberine on renal dysfunction and histological damages of the lung induced by renal ischemia/ reperfusion at an early stage. Methods: There were four experimental groups of adult male rats (n=7). Seven days before induction of ischemia, the Ber+I/R group received oral (by gavage) berberine (15 mg/kg/day) while the I/R group received distil...
متن کاملThe protective activity of noscapine on renal ischemia–reperfusion injury in male Wistar rat
Objective(s):Bradykinin is a part of the kinin-kallikreinsystem which is involved in ischemia-reperfusion injury via B1 and B2 receptors.Noscapine is a non-competitive antagonist of bradykinin receptors. Noscapine has been reported to to be able to protect some organs against ischemia-reperfusion injury but its effect on renal ischemia-reperfusion injury (RIR) in rats is unknown. Therefore, the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2013
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2012060560